Could Distribution of Ivermectin Prevent China’s Recent Mass COVID Outbreak?
China's state-run medicare program couldn't import more Paxlovid despite the drug being offered to the state at a reduced rate.
China’s state-run medicare program couldn’t agree with Pfizer to import more Paxlovid as the drug was too expensive despite the drug being offered to the state at a reduced rate than other developed countries. Lack of Paxlovid will leave only Azvudine, an anti-HIV drug the Chinese communist regime rushed through development and re-branded as an anti-COVID drug, as a treatment option.
Given the recent explosive spread of COVID and the resulting skyrocketing rates of hospitalization, finding viable treatment options is paramount.
Ivermectin in India and Peru
Many states in India offered ivermectin to a large population when the Delta variant broke out in 2021. It was found to be extremely effective in treating early and mild COVID-19 infections. Large states like Uttar Pradesh-home to 241 million residents- found using prophylactic dramatically reduced the infection rate and death toll.
Even among frontline health care workers, ivermectin proved to be an effective prophylactic against COVID-19. One study with 3,532 frontline health care workers from the All India Institute of Medical Sciences Bhubaneswar found that two doses of oral ivermectin (300 μg/kg given 72 hours apart) as chemoprophylaxis among health care workers reduced the risk of COVID-19 infection by 83 percent in the following month.
In Peru, mass ivermectin treatments were conducted through a broad-scale effort called Mega-Operación Tayta, or MOT for short. Operation MOT was led by the Peruvian army and involved 10 states, where the excess death rate saw a sharp decline with an average of 74 percent over 30 days. In 14 states where ivermectin was administered locally, the mean reduction in excess deaths over 30 days compared with deaths was 53 percent.
Lima, the capital of Peru, where the distribution of ivermectin was restricted, saw only a 25 per cent reduction in excess deaths. The findings of researchers, detailed in the diagram below, show infection numbers, deaths, and fatalities across Peruvian states which implemented ivermectin (blue) and those which did not (red). The conclusion is that a reduction in deaths correlated with the distribution of ivermectin with a statistically significant p-value of less than 0.002.
Ivermectin–The Wonder Drug
Ivermectin was discovered in Japan during the late 70s as a derivative of Avermectin, produced from a single organism isolated at the Kitasato Institute in Tokyo. Since then, ivermectin has played an immeasurable role in improving the lives of billions with its humble beginnings as an anti-parasitic drug.
Ivermectin, approved by the U.S. Food and Drug Administration and deployed worldwide since 1987, has made major inroads against two devastating tropical diseases—onchocerciasis and lymphatic filariasis. In addition, some topical forms of ivermectin are approved to treat external parasites like head lice and skin conditions such as rosacea.
In addition to its anti-parasitic effects, a 2022 study published in the European Journal of Medicinal Chemistry Reports found that ivermectin has a strong potency at low concentrations against many DNA and RNA viruses, including HIV-1, yellow fever, malaria, West Nile virus, Zika, dengue fever, etc.
According to the study, ivermectin has an amazing inhibitory effect across multiple species and can interrupt motility and reproduction in both arthropods (such as insects) and nematodes (such as roundworms). This explains why ivermectin is prescribed for parasite infections, and also sheds light on its potential as a prophylactic against vector-borne diseases. In insects and other arthropods specifically, it can interrupt the transmission of disease.
Ivermectin’s Potential Mechanisms Against COVID
SARS-CoV-2 is a virus that takes over host cells to multiply in the body. To enter the host cells, the virus binds to the ACE-2 receptor on the surface of cells which grants them entry. Ivermectin prevents the bonding process by interfering with the virus’s spike proteins—this is the same mechanism the vaccines use.
If the virus slips past the cell membrane, its top priority is to infiltrate the brain of the cell—the DNA-containing nucleus—to start mass-producing itself. SARS-CoV-2 latches itself onto a special class of transport proteins called IMPs that have enough security clearance to enter the nucleus. In the case of a viral infection, ivermectin binds to these transport proteins and halts the interaction.
Ivermectin also inhibits the nuclear transport mechanism mediated by the KPNA-1 protein, which has a similar effect when compared with IMPs. Both proteins can enter the nucleus and ivermectin can effectively stop the virus from getting to the nucleus. In the event that the virus does manage to invade the nucleus—ivermectin also has a backup plan.
For example, when the virus has taken over and initialized self-replication, it does so through a protein called RdRp, which is at the centerpiece of viral replication—and is directly inhibited by ivermectin with very high efficacy.
Ivermectin Could Reduce Severe Lung Damage in COVID Patients
Once COVID-19 reaches later stages, it may require intensive care for recovery. For example, white lung syndrome (a hallmark symptom of acute respiratory distress syndrome) now occurring in severe COVID infections in China, is a sign that the virus has deeply infected the lungs and may have caused cytokine storms (a severe immune reaction in the body) in patients.
Other complications that arise from COVID-19 involving the lungs are conditions such as pulmonary fibrosis and hypoxia. Hypoxia occurs when the virus infects lung tissue to the extent that the alveoli, tiny sacs of air at the end of lung branches responsible for oxygen exchange, become scarred causing a severe loss of oxygen in the body.
Cytokines and chemokines are responsible for inflammation, a natural immune system response to foreign invaders. However, a large number of cytokines released into the body all at once can cause a “cytokine storm,” wherein the body is flooded with armies of white blood cells that harm the body.
A cytokine storm can be triggered through the TLR-4 pathway by the virus. The same pathway also triggers the release of nitric oxide, causing fluid leaks, dilating blood vessels, or even sepsis and fluid buildup in the lungs.
A cytokine storm is related to the viral components that change how the body regulates certain signal molecules like STAT-3 and TLR-4. Too much STAT-3 will lead to the production of more TLR-4 through PAK-1 and is how the virus induces a pathway such that a heavy inflammatory response is initiated in the body.
Ivermectin directly inhibits the NF-kb and STAT-3 pathways by degrading the signal molecules that promote the vicious cycle. Thereby, Ivermectin can reduce the chance of cytokine storms and reduce the risk of patients having severe lung damage such as “white lungs.”
Ivermectin Can Reduce Bacterial Co-Infections for COVID Patients
Bacterial coinfections are common in respiratory viral infections, and patients with COVID-19 are no exception. Patients with co-infections were more likely to die in intensive care than those without coinfections. Among the group of compounds in the avermectin family, ivermectin stands out for its antibacterial effects.
In clinical isolates of multidrug-resistant tuberculosis, the use of ivermectin has been proven effective. At the same time, ivermectin inhibits the growth of a flurry of other bacteria such as Staphylococcus aureus (heavy skin infection), Mycobacterium Bovis, and others at clinically significant concentrations ranging from 1-8 µg/ml, signifying a strong potency.
Ivermectin can also activate P2X4 receptors in macrophages, increasing its ability to destroy bacteria and protect against sepsis, which is the most prominent antibacterial effect of ivermectin.
Repurposing drugs, if successful, is the best accelerator for prophylactic development because it can save developers anywhere from three to 12 years as experts can reuse the data from previous clinical trials and other experiments.
A “wonder drug” like ivermectin should be strongly considered as a defense against viruses given its success both in mechanism studies and clinical trials as well as applications in a variety of diseases and infections. The suppression of ivermectin usage during the COVID-19 pandemic by government agencies and Big Pharma is one of the world’s most tragic events in modern medicine.
Particularly sad was when the Chinese regime did not fulfill its social responsibilities when loosening the zero-COVID restrictions by offering prophylactics such as ivermectin to prepare its people for a tsunami of infections—as Peru did with their ivermectin distribution operation. It would have been greatly beneficial to equip the Chinese people with ivermectin to reduce the exorbitant infection numbers and needless deaths of COVID-19.