Pfizer mRNA Vaccine Makes ‘Aberrant Proteins’, Experts Concerned About Autoimmunity Events
Authored by Marina Zhang via The Epoch Times
There may be around a 1 in 10 chance that Pfizer mRNA COVID-19 vaccines will not generate spike proteins but something else, a new Cambridge study finds, raising concerns about autoimmune response among experts.
The study authors found that 8 percent of the time, Pfizer mRNA COVID-19 vaccines are mistranslated, leading to the formation of unintended proteins.
“Our work presents both a concern and a solution for this new type of medicine,” said leading author Anne Willis in the study’s press release.
One can think of mRNA vaccines as a set of instructions used to make spike proteins. Once the vaccine enters the cell, ribosomes interpret the mRNA instructions to make proteins, like spike proteins.
If the instructions are misinterpreted, errors in the final protein may be produced. Some errors are minor, like misspelling one word in a text, while others are more detrimental.
This misinterpretation is called a frameshift, which occurs when one or two mRNA bases are skipped. Since mRNA bases are translated in sets of threes, skipping a base would affect all the sequences downstream, leading to new proteins being formed.
“Frameshifting results in the production multiple, unique and potentially aberrant proteins,” immunologist Jessica Rose wrote in her Substack article discussing the study.
While most naturally occurring mRNA contains uridine, the Pfizer mRNA vaccines use N1-methylpseudouridine. This makes the mRNA sequence hardier and less prone to breakdown by the immune system. Pfizer’s opting for less commonly occurring mRNA bases is also why some scientists call the mRNA vaccines modified RNA, or modRNA.
By implementing additional edits to the mRNA sequences, the authors were able to reduce further frameshifted proteins.
Although “there is no evidence: that the aberrant proteins generated by Pfizer vaccination are associated with adverse outcomes, for future use of mRNA technology, it is important that “mRNA sequence design is modified” to reduce these shifts, the authors concluded.
Apart from frameshift errors, the N1-methylpseudouridine modification can also slow down and interrupt mRNA translation to protein, potentially leading to shorter-than-expected protein sequences.
“Under ideal circumstances, ribosomes translate the vaccine mRNA into the S [spike] protein … If the cellular machine (ribosomes) ‘detect’ the difference [between normal uridine and N1-methylpseudouridine], it can result in stalling or mistranslation,” Dr. Adonis Sfera, assistant clinical professor of medicine at Loma Linda University, wrote to The Epoch Times via email.
In the study, the researchers first inoculated mice with both Pfizer and AstraZeneca vaccines. They found that Pfizer vaccines were significantly more likely to produce frameshifted proteins.
Researchers then compared vaccine inoculations in humans, comparing 21 participants who took the Pfizer vaccine to 20 who took the AstraZeneca vaccine. None of the AstraZeneca vaccinees had an immune reaction to proteins made from mistakes in translation, but around one-third of the Pfizer vaccinees did.
